Gerhard Franz, Roger A. Sheldon "Oxidation" in. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals. 322, 4855 (2012), K. Tamura, T. Kasuga, T. Nakagawa, Fluid Phase Equilib. However, hydroquinone discolors at the pH range of 7.0 to 8.5. Solubilities of hydroquinone and p-quinone in - ScienceDirect Johnson & Johnson Consumer Products, Inc. Johnson & Johnson Consumer Companies, Inc. AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR, STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN, Color Stability of 4% HQ Compositions with varying pH and % Sodium Metabisulfite at 5C and 40C, Color Stability of 4% HQ Compositions with varying pH and % Magnesium Ascorbyl Phosphate at 5C and 40C, Polyacrylamide (and) C 13-14 isoparaffin (and) laureth-7, Water, Soybean (Glycine Soja) Oil, Carnauba (Copemicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Water, Soybean (Glycine Soja) Oil, Carnauba (Copernicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Compositions for the treatment of pigmentation disorders and methods for their manufacture, Stabilization composition including hydroquinone or derivative thereof, Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof, Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent, Depigmenting composition for the skin, use of a depigmenting composition for the skin, cosmetic use of the same and method for non-therapeutic cosmetic treatment, Cosmetic designs and products using intronic RNA, Holistic composition and method for reducing skin pigmentation, Topical compositions and methods of manufacturing them in specifically treated steel vessels, System for improved percutaneous absorption of skin benefiting agents, Discontinuous surface coating for particles, Method of treating skin requiring chemical peel procedure, Method of treating skin needing hyaluronic acid treatment, Method of treating skin having incision from surgical procedures, Method of treating skin requiring hair removal procedure, Method of treating skin requiring Intense Pulse Light (IPL) procedure, Method of treating skin subject to or affected by aesthetic surgical procedures, Method of treating skin needing ablative treatment, Method of treating skin requiring radiofrequency procedure, Method of treating skin requiring non-ablative procedure, Method of treating skin requiring fractional resurfacing treatment, Method of treating skin needing botulinum toxin type a treatment, Method of treating skin requiring microdermabrasion, Method of treating skin needing collagen treatment, Method of treating skin requiring skin cancer treatment, Methods of treating skin to enhance therapeutic treatment thereof, Ras mutation and compositions and methods related thereto, Compositions, kits and regimens for the treatment of skin, especially dcolletage, Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions. Privacy Policy. A common route involves hydroxylation of phenol. 0000004433 00000 n PDF HYDROQUINONE - Centers for Disease Control and Prevention 77, No. One of these, 4-butylresorcinol, has been proven to be more effective at treating melanin-related skin disorders by a wide margin, as well as safe enough to be made available over the counter. This compound is gathered from the beaver's castor sacs.[35]. The color stability of the hydroquinone composition is promoted by one or more antioxidants in the hydroquinone phase, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate. 0000005089 00000 n HYDROQUINONE (DIHYDROXYBENZENE) | Occupational Safety and Health We have discovered that a hydroquinone composition (with about 1 to about 12% hydroquinone, preferably with about 2% to about 10%, more preferably with about 2% to about 8%, more preferably with about 2% to about 4%, most preferably with about 3% to about 4% hydroquinone) with preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, can include cationic salts of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate as an antioxidant and the color destabilization problems are appreciably less as compared to hydroquinone compositions without such a cationic salt of acidic ascorbyl esters in the neutral pH range: preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. 0000004197 00000 n By clicking Accept, you consent to the use of cookies. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. A2, Designated state(s): Variations in pH have proven to result in excessive discoloration ranging from brownish to black. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Conversion factors (at 25 oc and normal atmospheric pressure) 1 ppm = 4.5 mg!m 3 Other solubilities: soluble in alcohol and ether,slightly soluble in benzene,readily soluble in ethanol,acetone and methanol, Needle-like Crystals or Crystalline Powder. Hydroquinone, like phenols are very weak acids and can be deprotonated. Hydroquinone is an aromatic organic compound which is currently used in two main sectors: . The document was not able to download due to an unknown error. hydroquinone, 1,4-benzenediol, quinol, 1,4-dihydroxybenzene, p-benzenediol, 4-hydroxyphenol, p-hydroquinone, p-hydroxyphenol, p-dihydroxybenzene, benzoquinol, Electrophoresis, Western Blotting and ELISA, Chromatography and Mass Spectrometry Reagents, Laboratory Syringe Needles and Accessories, Lab Coats, Aprons, and Other Safety Apparel, Sharps Disposal Containers and Accessories, Classroom Laboratory Supplies and Consumables, Applied Biosystems TaqMan Assay and Arrays Search Tool, Applied Biosystems TaqMan Custom Assay Design Tools, Applied Biosystems Custom qPCR Primers and TaqMan Probes Tool, Chemical Storage and Management Resource Center, Solubility in water: 70g/L in water (20C). Some documentation and label information may refer to the legacy brand. Hydroquinone - an overview | ScienceDirect Topics These phases (described below) are combined in a mixing tank with an in-line homogenizer as follows. I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. Glycerol derivatives solubilise natural, hydrophilic antioxidants in biofuels. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. Rev. Eastman has active ingredients, thickeners, plasticizers, film formers, and more for your personal care formulations. Classical photo shops . 0000002544 00000 n Data 53, 199200 (2008), N. Sunsandee, S. Suren, N. Leepipatpiboon, M. Hronec, U. Pancharoen, Fluid Phase Equilib. vitamin C; Salts thereof, Medicinal preparations containing active ingredients not provided for in groups A61K31/00-A61K41/00, Mixtures of active ingredients without chemical characterisation, e.g. Although about 0.01% sodium metabisulfite without magnesium ascorbyl phosphate may not color stabilize an about 4% hydroquinone composition, and about 0.5% magnesium ascorbyl phosphate without sodium metabisulfite may not either, the combination of sodium metabisulfite and magnesium ascorbyl phosphate in these percentages is effective to stabilize the color of the about 1% to about 12%, about 2% to about 10%, preferably about 2% to about 8% and more preferably about 3% to about 4% and most preferably 4% hydroquinone composition. Except where otherwise noted, data are given for materials in their, Hydroquinone oxidation with V2O5/NaClO3/H2SO4, http://www.sciencemadness.org/smwiki/index.php?title=Hydroquinone&oldid=11523, Articles containing unverified chemical infoboxes, GNU Free Documentation License 1.3 or later. [Na+].OC(=O)CC(O)(CC([O-])=O)C(O)=O.OC(=O)CC(O)(CC([O-])=O)C(O)=O, SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS, Preparations for care of the skin for chemically bleaching or whitening the skin, PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES, Medicinal preparations containing organic active ingredients, Acids; Anhydrides, halides or salts thereof, e.g. Get medical attention. They may also include ingredients with other therapeutic actions, such as anti-inflammatories, antibiotics, exfoliants and peels. 2008-2023 ChemPoint. Eng. vz >I d50dwp?i4,H3. 2017-02-16T10:10:56+01:00 New experimental data are provided for the solubility of resorcinol in water and salicylic acid, resorcinol, hydroquinone in 1-octanol. The 10 Best Hydroquinone Creams to Buy in 2023 - Beauty Mag Our team has been notified and we will fix it as soon as possible. Some hydroquinone compositions include antioxidants, such as ascorbyl palmitate. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. 2005 Wiley-VCH, Weinheim. antiphlogistics and cardiaca, Cosmetics or similar toilet preparations characterised by the composition, Cosmetics or similar toilet preparations characterised by the composition containing inorganic ingredients, Sulfur; Selenium; Tellurium; Compounds thereof, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen, . Therefore, the solubility values of hydroquinone in different solvents are required; however, the data availability in the literature is poor.3-7 In this work, the solubility data of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid from 276.65 K to 345.10 K under atmospheric pressure were . 1401417, Country of ref document: If you are already a ChemPoint customer then sign up for access to our online ordering website. 2 Liquid phase only; silicon dioxide remains as a residue in these solvents. The obtained results show that the solubility of benzoic acid in water is greater than that of salicylic acid, but in the case of the two isomers of dihydroxybenzene, the solubility of resorcinol is approximately 100 times that of hydroquinone. Stabilisation of biofuels with hydrophilic, natural antioxidants [33], Hydroquinone has been shown to be one of the chemical constituents of the natural product propolis. This chamber is lined with cells that secrete catalases and peroxidases. Hydroquinone is combustible when preheated. Res. Hydroquinone[1] Idrochinone Quinol 1,4-Dihydroxybenzene p-dihydroxybenzene p-hydroxyphenol 1,4-Hydroxy benzene Identifiers CAS Number 123-31-9 Y 3D model (JSmol) Interactive image Beilstein Reference 605970 ChEBI CHEBI:17594 Y ChEMBL ChEMBL537 Y ChemSpider 764 Y DrugBank DB09526 ECHA InfoCard 100.004.199 EC Number 204-617-8 Gmelin Reference 2742 It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. I've been presented with the problem of trying to dissolve Hydroquinone in a solvent other than water. Remove contact lenses, if present and easy to do. Acta 423, 137144 (2000), S.-T. Lin, S. I. Sandler, Ind. Hydroquinone is used as a topical application in skin whitening to reduce the color of skin. Thermodyn. Human exposure to hydroquinone can occur by dietary, occupational, and environmental sources. A further embodiment of the invention includes a method for stabilizing a hydroquinone composition (with about 1% to about 12% hydroquinone, preferably about 2% to about 10%, more preferably about 2% to about 8%, and most preferably about 3% to about 4%) with a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, by adding a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate. English, J.C. and Deisinger, P.J. The Boiling Point of hydroquinone is 287C Also, the Melting Point of hydroquinone is 172C. Cookie Notice STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN. D-170D Solubility of EASTMAN Hydroquinone and Derivatives Subject: Hydroquinone and hydroquinone derivatives listed in this publication are used as intermediates for manufacturing a variety of products and as polymerization inhibitors for vinyl monomers and unsaturated polyester resins. If youre making your lotion. Thus, merely adding one retinoid to a hydroquinone composition would result in instability and/or discoloration, and adding hydroquinone to a retinoid product would have a similar result. This saturated dicarboxylic acid exists as a white powder. Hi, let us know if you have any questions as you visit our website. The composition is preferably formulated in separate phases as designated below. Hydroquinone Revision Date 24-Dec-2021 General Advice If symptoms persist, call a physician. Phase B: Dissolve the ferulic acid in the glycerin - some "spirited" stirring may be necessary. Using a laser-monitoring observation technique, the solubility of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid were measured at temperatures ranging from 276.65 K to 345.10 K under the atmospheric pressure. At 40C, 4% hydroquinone compositions have the same color stability with slightly more sodium metabisulfite, at least about 0.01% at about 3.5 to about 4.0 pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at least about 0.10% sodium metabisulfite at about 6.5 to about 7.0 pH. The combined nearly ideal binary solvent (NIBS)-Redlich-Kister equation is . Stir until uniform. 0000008435 00000 n endstream endobj 277 0 obj <>stream Protected retinoid may be added to these compositions for additional skin benefit effects. I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. I've been presented with the problem of trying to dissolve Hydroquinone in a solvent other than water. Belhachemi, B., Makhlouf, H. & Belhachemi, M.H. One embodiment of the invention is a composition which comprises hydroquinone (about 1% to about 12%, preferably about 2% to about 10%, more preferably about 2% to about 8%, more preferably with about 2% to about 4%, and most preferably about 3% to about 4%) and has a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. 552591, Z. Esina, M. Korchuganova, Theor. RJPT - Hydroquinone Solubility in Pure and Binary Solvent Mixture at Appearance: Free-flowing white crystalsOdor: OdorlessMolecular weight: 110.11Empirical formula: C6H6O2Assay (Anhydrous basis): 99.0-100.5 %Melting point: 172-174CWater: 0.5 wt % max.Residue on ignition: 0.5 % maxSolubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol, Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMOExtremely low vapor pressureUSP GradeEuropean Pharma GradeDrug master file available upon request. Read our Privacy Notice. The most preferred example of such an antioxidant is sodium metabisulfite. trailer << /Size 393 /Info 347 0 R /Root 375 0 R /Prev 573815 /ID[<6893db2526a970a0c364cca2e99ca522>] >> startxref 0 %%EOF 375 0 obj << /Type /Catalog /Pages 346 0 R /Metadata 348 0 R >> endobj 391 0 obj << /S 2217 /Filter /FlateDecode /Length 392 0 R >> stream
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